During mitosis, a full set of chromosomes must be equally transmitted to the offspring of each dividing cell. Failures in this process can result in numerous disorders, including birth defects and tumor progression. The Funabiki Lab studies how chromosomes signal in order to spatially and temporally orchestrate rapid assembly and disassembly of macromolecules that ensure accurate chromosome segregation.
Laboratory of Chromosome and Cell Biology,
The Rockefeller University
During mitosis, a full set of chromosomes must be equally transmitted to the offspring of each dividing cell. Failures in this process can result in numerous disorders, including birth defects and tumor progression. The Funabiki lab studies the mechanisms by which accurate chromosome segregation is ensured and the consequences resulting from mitotic failures.
