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Structural Mechanics of the Alpha-2-Macroglobulin Transformation

Yasuhiro Arimura and Hironori Funabiki Published in Journal of Molecular Biology, Mar 2022 (Link) Highlights - 3.6–4.1 Å resolution...

Structural features of nucleosomes in interphase and metaphase chromosomes

Yasuhiro Arimura, Rochelle M. Shih, Ruby Froom, Hironori Funabiki Published in Molecular Cell online, Sep 2021 (Link) Highlights - 3.4-Å...

Linker histone H1.8 inhibits chromatin-binding of condensins and DNA topoisomerase II to tune chromo

Pavan Choppakatla, Bastiaan Dekker, Erin E Cutts, Alessandro Vannini, Job Dekker, Hironori Funabiki Published in eLife 10, Aug 2021...

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Simona Giunta, Solène Hervé, Ryan R White, Therese Wilhelm, Marie Dumont, Andrea Scelfo, Riccardo Gamba, Cheng Kit Wong, Giulia Rancati,...

Structural basis for the inhibition of cGAS by nucleosomes

Tomoya Kujirai, Christian Zierhut, Yoshimasa Takizawa, Ryan Kim, Lumi Negishi, Nobuki Uruma, Seiya Hirai, Hironori Funabiki, Hitoshi...

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

Zierhut, C. et al. The cytoplasmic DNA sensor cGAS promotes mitotic cell death. Cell. 178, 302–315 (2019)

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

Christopher Jenness, Simona Giunta, Manuel M. Müller, Hiroshi Kimura, Tom W. Muir, and Hironori Funabiki Published in PNAS...

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

Simona Giunta and Hironori Funabiki Significance The centromere is a highly specialized genomic locus playing a critical role in...

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