Structural Mechanics of the Alpha-2-Macroglobulin Transformation
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During mitosis, a full set of chromosomes must be equally transmitted to the offspring of each dividing cell. Failures in this process can result in numerous disorders, including birth defects and tumor progression. The Funabiki Lab studies how chromosomes signal in order to spatially and temporally orchestrate rapid assembly and disassembly of macromolecules that ensure accurate chromosome segregation.
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