Our Research

During mitosis, a full set of chromosomes must be equally transmitted to the offspring of each dividing cell. Failures in this process can result in numerous disorders, including birth defects and tumor progression. The Funabiki Lab studies how chromosomes signal in order to spatially and temporally orchestrate rapid assembly and disassembly of macromolecules that ensure accurate chromosome segregation.

Funabiki Laboratory

Laboratory of Chromosome and Cell Biology,

The Rockefeller University

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CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

CENP-A chromatin prevents replication stress at centromeres to avoid structural aneuploidy

Simona Giunta, Solène Hervé, Ryan R White, Therese Wilhelm, Marie Dumont, Andrea Scelfo, Riccardo Gamba, Cheng Kit Wong, Giulia Rancati,...

Structural basis for the inhibition of cGAS by nucleosomes

Structural basis for the inhibition of cGAS by nucleosomes

Tomoya Kujirai, Christian Zierhut, Yoshimasa Takizawa, Ryan Kim, Lumi Negishi, Nobuki Uruma, Seiya Hirai, Hironori Funabiki, Hitoshi...

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

The Cytoplasmic DNA Sensor cGAS Promotes Mitotic Cell Death

Zierhut, C. et al. The cytoplasmic DNA sensor cGAS promotes mitotic cell death. Cell. 178, 302–315 (2019)

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

HELLS and CDCA7 comprise a bipartite nucleosome remodeling complex defective in ICF syndrome

Christopher Jenness, Simona Giunta, Manuel M. Müller, Hiroshi Kimura, Tom W. Muir, and Hironori Funabiki Published in PNAS...

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

Integrity of the human centromere DNA repeats is protected by CENP-A, CENP-C, and CENP-T

Simona Giunta and Hironori Funabiki Significance The centromere is a highly specialized genomic locus playing a critical role in...